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바이오스펙트럼은 연구개발 전문기업으로 매년 5~6편의 SCI급 저널의 연구결과를 발표하고 있습니다. 특히 공동연구를 많이 진행하여 타 연구팀들과의 공동발표도 활발히 하고 있습니다. 사업화를 위한 전략으로 공동발표도 가능함으로 신규소재 사업화시 당사와 사전 협의 하시면 외국의 유명저널에 공동발표가 가능한 수준의 공동연구도 가능합니다. 장기적으로 매년 20여편의 SCI급 논문발표를 목표로 하고 있습니다.

논문 발표 현황


SCI/E Journals : 89

  • 1. In vitro antibacterial and anti-inflammatory activities of Honokiol and Magnolol against Propionibacterium sp.
    European Journal of Pharmacology, 2004, 496(1-3):189-195.
  • 2. Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation.
    Journal of Ethnopharmacology, 2005, 96(1-2):211-219.
  • 3. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of downstream pathway of the MEKK-1 in NF-kB activation signaling.
    Planta Medica, 2005, 71(4):338-343.
  • 4. Glycyrrhizin(GR) induces melanogenesis by elevating a cAMP level in B16 melanoma cells.
    The Journal of Investigative Dermatology, 2005, 124(2):405- 411.
  • 5. Transdermal delivery of interferon γ (IFNγ) mediated by penetratin, a cell-permeable peptide.
    Biotechnology and applied Biochemistry, 2005, 42(2):169-173.
  • 6. Asiaticoside induces Human Collagen I Synthesis through TGFβ receptor I kinase (TβRI kinase)-independent Smad signaling.
    Planta Medica, 2006, 72(4):324-328.
  • 7. Rosmarinic acid (RA) as a downstream inhibitor of IKK β in TNF α-induced upregulation of CCL11 & CCR-3.
    British Journal of Pharmacology, 2006, 148:366-375.
  • 8. Involvement of nuclear factor-kB in the inhibition of pro-inflammatory mediators by pinosylvin.
    Planta Medica, 2006, 72(9):801-806.
  • 9. Emodin inhibits TNF α-induced MMP-1 expression through suppression of JNK and p42/44MAPK.
    Life Sciences, 2006, 79:2480-2485.
  • 10. Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling.
    Journal of Ethnopharmacology, 2007, 109:29-34.
  • 11. A cell-based assay system for high-throughput screening of anti-wrinkle agents in human dermal fibroblast transfectant cells.
    Biotechnology and applied Biochemistry, 2007, 47(1):27-31.
  • 12. Effect of Camellia japonica oil on human type I procollagen production and skin barrier function.
    Journal of Ethnopharmacology, 2007, 112:127-131.
  • 13. Diosgenin inhibits melanogenesis through the activation of Phosphatidylinositol-3- kinase Pathway (PI3K) signaling.
    Life Sciences, 2007, 81(3):249-254.
  • 14. Mechanisms of melanogenesis inhibition by DMHF.
    British Journal of Dermatology, 2007, 157(2):242-248.
  • 15. Rosmarinic acid induces melanogenesis through protein kinase A activation signaling.
    Biochemical Pharmacology, 2007, 74(7):960-968.
  • 16. Matrine inhibits PMA-induced MMP-1 expression in human dermal fibroblasts.
    Biofactors, 2008, 33(2):121-128.
  • 17. Antibacterial activities of Butyrolactone from Spiraea thunbergii Sieb. against foodborne pathogenic microorganisms.
    Journal of Medicinal Plants Research, 2008, 2(3):59-65.
  • 18. Mechanisms of depigmentation by α-bisabolol.
    Journal of Dermatological Science, 2008, 52(3):219-222.
  • 19. Mechanisms of carvacrol-induced expression of type I collagen gene.
    Journal of Dermatological Science, 2008, 52(3):160-169.
  • 20. Effect of rosmarinic acid on patients with atopic dermatitis.
    Journal of Dermatology, 2008, 35(12):768 771.
  • 21. Effect of a preparation containing asiaticoside on periocular wrinkles of human voluntaries.
    International Journal of Cosmetic Science, 2008, 30(3):167-173.
  • 22. Isorhamnetin represses adipogenesis in 3T3-L1 cells.
    Obesity, 2009, 17(2):226-232.
  • 23. 6-benzylaminopurine (6-BAP) stimulates the melanogenesis by cAMP independent activation of Protein kinase A (PKA).
    Archives of Dermatological Research, 2009, 301(3):253-258.
  • 24. A cell-based system for screening hair growth-promoting agents.
    Archives of Dermatological Research, 2009, 301(5):381-385.
  • 25. Promotion of stem cell proliferation by vegetable peptone.
    Cell proliferation, 2009, 42(5):595-601.
  • 26. Phloridzin-induced melanogenesis is mediated by cAMP signaling pathway.
    Food & Chemical Toxicology, 2009, 47(10):2436-2440.
  • 27. Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant.
    Environmental Toxicology and Pharmacology, 2010, 29:12-18.
  • 28. Synthesis and microbiological evaluation of honokiol derivatives as new antibacterial agents.
    Archives of Pharmacal Research, 2010, 33(1):61-65.
  • 29. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR γ through JNK-dependent upregulation of iNOS.
    Cellular and Molecular Life Sciences, 2010, 67(3):467-481.
  • 30. Isorhamnetin-induced antiadipogenesis is mediated by stabilization of β-catenin protein.
    Life Sciences, 2010, 86(11-12):416-423.
  • 31. Enzymatic transformation of platycosides and one step separation of platycodin D by high-speed counter-current chromatography.
    Journal of Separation Science, 2010, 33(13):1916-1922.
  • 32. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis.
    Biological & Pharmaceutical Bulletin, 2010, 33(7):1242-1245.
  • 33. Whitening effect of α-bisabolol in Asian women.
    International Journal of Cosmetic Science, 2010, 32(4):299-303.
  • 34. Mechanisms of depigmentation by propafenone.
    Archives of Dermatological Research, 2010, 302(7):561-565.
  • 35. Melanocyte-Precursor Cell Induction from Human Cord Blood-Derived Mesenchymal Stem Cells.
    African Journal of Biotechnology, 2010, 9(36):5975-5977.
  • 36. Ultraviolet A regulates adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via upregulation of Kruppel-like factor 2.
    The Journal of Biological Chemistry, 2010, 285(42):32647-32656.
  • 37. Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signaling pathways.
    International Journal of Molecular Sciences, 2010, 11(11):4348-4360.
  • 38. Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages.
    Food & Chemical Toxicology, 2011, 49(10):2580-2585.
  • 39. Depigmentation by platycodin D is mediated by cAMP-PKA/Rho-dependent signaling pathway.
    Experimental Dermatology, 2011, 20(12):986-991.
  • 40. Simple stability-indicating validated HPLC method for diosgenin in cosmeceutical formulations.
    International Journal of Pharmacy and Pharmaceutical Sciences, 2011, 3(suppl 5):466-471.
  • 41. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells.
    Evidence Based Complementary Alternative Medicine, 2012, 2012:797520:11.
  • 42. Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1.
    The Journal of Nutritional Biochemistry, 2012, 23(10):1141-1151.
  • 43. Inhibitory effects of Camellia japonica oil on LPS-induced inflammatory response in RAW264.7 macrophages.
    BMB Reports, 2012, 45(3):177-182.
  • 44. Artemisinic Acid is a Regulator of Adipocyte Differentiation and C/EBP δ Expression.
    Journal of Cellular Biochemistry, 2012, 113(7):2488-2499.
  • 45. Baicalein Attenuates Oxidative Stress-Induced Expression of Matrix Metalloproteinase-1 by Regulating the ERK/JNK/AP-1 Pathway in Human Keratinocytes.
    Biomolecules & Therapeutics, 2012, 20(1):57-61.
  • 46. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE2-cAMP signaling.
    Journal of Cellular Biochemistry, 2012, 113(12):3681-3691.
  • 47.Isomenthone protects human dermal fibroblasts from TNF α-induced cell death in serum-deprived condition.
    Food and Chemical Toxicology, 2012, 50(10):3514-20.
  • 48. A Novel Antibacterial Compound from Siegesbeckia glabrescens.
    Molecules, 2012, 17:12469-12477.
  • 49. The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression.
    Oncology Reports, 2013, 29(3):917-924.
  • 50. Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress.
    Evidence-Based Complementary and Alternative Medicin, 2013, Volume 2013
  • 51. Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes.
    Food chemistry, 2013, 141(1):174-81.
  • 52. Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene.
    Food and Chemical Toxicology, 2013, 51:225-30.
  • 53. Phloridzin isolated from Acanthopanax senticosus promotes proliferation of α6 integrin (CD 49f) and β1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway.
    Archives of Dermatological Research, 2013, 305(8):747-54.
  • 54. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damages.
    PLOS one, 2013, 8(4):e61971.
  • 55. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling.
    Food and Chemical Toxicology, 2013, 58:423-31.
  • 56.Antagonist effects of veratric acid against UVB-induced cell damages.
    Molecules, 2013, 18(5):5405-19.
  • 57. Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation.
    Molecules, 2013, 18(12):15724-15736.
  • 58. Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress.
    Evidence-Based Complementary and Alternative Medicine 2013 Volume 2013, Article ID 983609: 10
  • 59. 7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways.
    International Journal of Molecular Medicine 2014, 33(4):964-970.
  • 60. Synephrine Inhibits Eotaxin-1 Expression via the STAT6 Signaling Pathway.
    Molecules 2014, 19(8):11883-11895.
  • 61. Protective effects of a new phloretin derivative against UVB-induced damage in skin cell model and human volunteers.
    International Journal of Molecular sciences 2014, 15(10):18919-18940.
  • 62. Vegetable peptones increase production of type I collagen in human fibroblasts by inducing the p90 ribosomal s6 kinase-CCAAT/enhancer binding protein β phosphorylation pathway.
    Nutr Res. 2015, 35(2):127-35.
  • 63. A novel culture system to induce synthesis in ultra-low attachment plate.
    Biotechnology and Bioprocess Engineering, 2015, Volume 20, Issue 1, pp 194 200.
  • 64. Anti-Glycation Activities of Phenolic Constituents from Silybum marianum (Milk Thistle) Flower in Vitro and on Human Explants.
    Molecules 2015, 20, 3549-3564.
  • 65. Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells.
    PLoS One. 2015, 10(4):e0124417.
  • 66. Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products.
    Nutrients. 2015, 7(11):9337-52.
  • 67. The Antiaging Properties of Andrographis paniculata by Activation Epidermal Cell Stemness.
    Molecules. 2015, 20(9):17557-69.
  • 68. Cell-based assay system for high-throughput screening of anti-photo-aging agents in fibroblast transfectants.
    Cytotechnology. 2016, 68(4):1633-40.
  • 69. Development of Tyrosinase Promoter-Based Fluorescent Assay for Screening of Anti-melanogenic Agents.
    Biol Pharm Bull. 2015;38(10):1542-7.
  • 70. Evaluation of anti-acne properties of phloretin in vitro and in vivo.
    Int J Cosmet Sci. 2016, 38(1):85-92.
  • 71. Inhibition of melanogenesis by Gaillardia aristata flower extract.
    BMC Complement Altern Med. 2015, 15:449.
  • 72. Physiological Functions of the COPI Complex in Higher Plants.
    Mol Cells. 2015, 38(10):866-75.
  • 73. A study of facial wrinkles improvement effect of veratric acid from cauliflower mushroom through photo-protective mechanisms against UVB irradiation.
    Arch Dermatol Res. 2016, 308(3):183-92.
  • 74. Sclareol isolated from Salvia officinalis improves facial wrinkles via an antiphotoaging mechanism.
    J Cosmet Dermatol. 2016 Jul 28.
  • 75. Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.
    Chem Biol Interact. 2016, 250:78-84.
  • 76. Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen.
    Oxid Med Cell Longev. 2016; 2016:3859721.
  • 77. Afzelin positively regulates melanogenesis through the p38 MAPK pathway.
    Chem Biol Interact. 2016, 254:167-72.
  • 78. Anti-inflammatory effects of Zea mays L. husk extracts.
    BMC Complement Altern Med. 2016, 16(1):298
  • 79. Melanocyte-protective effect of afzelin is mediated by the Nrf2-ARE signalling pathway via GSK-3β inactivation.
    Exp Dermatol. 2017, 26(9):764-770
  • 80. Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation.
    Arch Dermatol Res. 2017, 309(5):381-388.
  • 81. Zingerone protects keratinocyte stem cells from UVB-induced damage.
    Chem Biol Interact. 2018, 279:27-33.
  • 82. Protective Effect of Mulberry (Morus alba L.) Extract against Benzo[a]pyrene Induced Skin Damage through Inhibition of Aryl Hydrocarbon Receptor Signaling.
    J Agric Food Chem. 2017, 65(50):10925-10932.
  • 83. Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes.
    Br J Dermatol. 2018, 179(3):689-701.
  • 84. PER, a Circadian Clock Component, Mediates the Suppression of MMP-1 Expression in HaCaT Keratinocytes by cAMP.
    Molecules. 2018, 23(4).
  • 85. Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica.
    Int J Mol Sci. 2018, 19(9).
  • 86. Anti-Thermal Skin Aging Activity of Aqueous Extracts Derived from Apple Mint (Mentha suaveolens Ehrh.) in Human Dermal Fibroblasts.
    Evid Based Complement Alternat Med. 2018, 2018:4595982.
  • 87. Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells.
    Evid Based Complement Alternat Med. 2018, 2018:1762478.
  • 88. . nc886, a non-coding RNA, inhibits UVB-induced MMP-9 and COX-2 expression via the PKR pathway in human keratinocytes.
    Biochem Biophys Res Commun. 2019. pii: S0006-291X(19)30082-8.
  • 89. Protective effects of Camellia japonica flower extract against urban air pollutants.
    BMC Complement Altern Med. 2019, 19(1):30.

Non-SCI/E Journals : 25

  • 1.Effect of Kojic acid, Arbutin and Vitamin C on cell viability and melaninsynthesis in B16BL6 cells.
    Journal of the Society of Cosmetic Scientists of Korea, 2003, 29(1):151-167.
  • 2. Evaluation of the Anti-inflammatory and immunomodulatory effects of BSASM using in vitro experiments.
    Koran Journal of Pharmacology, 2003, 34(3):228-232.
  • 3. Correlation between skin roughness and dermal density of skin wrinkle evaluation.
    Journal of the Society of Cosmetic Scientists of Korea, 2006, 32(2):123-127.
  • 4. Herbal extracts as a NF-kappaB inhibitor.
    Journal of the Society of Cosmetic Scientists of Korea, 2006, 32(3):135-140.
  • 5. Preliminary screening of some Jeju island native plants for whitening and antioxidant activity.
    Journal of the Society of Cosmetic Scientists of Korea, 2006, 32(3):161-171.
  • 6. Anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multiherbal preparation.
    Recent Progress in Medicinal Plants, 2006, 12:221-237, Review.
  • 7. Antibacterial effects of medicinal plants from Jeju island against acne-inducing bacteria.
    Journal of Applied Biological Chemistry, 2007, 50(2):101-103.
  • 8. The study on anti-obesity activity of the wild plants of Jeju Island.
    Journal of the Society of Cosmetic Scientists of Korea, 2007, 33(3):175-179.
  • 9. In vitro screening of Jeju medicinal plants for cosmeceutical materials.
    Journal of Applied Biological Chemistry, 2007, 50(4):215-220.
  • 10. The study on antimicrobial and antifungal activity of the wild seaweeds of Jeju Island.
    Journal of the Society of Cosmetic Scientists of Korea, 2008, 34(3):201-207.
  • 11. Effects of Vegetable Peptones on Promotion of Cell Proliferation and Collagen Production.
    Journal of the Society of Cosmetic Scientists of Korea, 2009, 35(1):65-72.
  • 12. Antibacterial and anti-inflammatory effects of a Magnolia extract.
    Cosmetics & Toiletries, 2009, 124(1):53-60.
  • 13. A medicinal plant blend for soothing and anti-nflammatory effects.
    Cosmetics & Toiletries, 2009, 124(4):34-41.
  • 14. Inhibitory effects of serotonin derivatives isolated from safflower seed extract on adipogenesis.
    Journal of the Society of Cosmetic Scientists of Korea, 2011, 37(2):171-176.
  • 15. Inhibitory Effect of Artemisinic Acid Isolated from Artemisia Annua L on the MDC in HaCaT Keratinocytes.
    Korean Journal of Pharmacognosy, 2012, 43(3):217- 223.
  • 16. Functional Characterization of Callus Extracts of Apple ‘Hirosaki’ for Cosmetic Materials.
    Korean Society for Biotechnology and Bioengineering Journal, 2013, 28(4): 244-248.
  • 17. Determination of p-Anisic Acid and Methylparaben by Using High Performance Liquid Chromatography.
    Journal of the Society of Cosmetic Scientists of Korea, 2014, 40(4):359-364.
  • 18. Effect of Extraction Condition on the Antioxidant Activity of Hypochoeris radicata Flower Extracts.
    The Korean Society of Cosmetics and Cosmetology. 2015, 05(2), 169-177
  • 19. Anti-Inflammatory and Anti-allergic Effects of Gnaphalium affine Extract.
    J. Soc. Cosmet. Sci. Korea 2017, 43(2): 103-114.
  • 20. Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer.
    Cosmetics 2017, 4, 18; doi:10.3390/cosmetics4020018
  • 21. Effect and Tolerability of the Combined Plant Extract (PAC) in Treatment of Acne Vulgaris.
    Journal of Cosmetics, Dermatological Sciences and Applications, 2018, 8: 55-72.
  • 22. Unripe citrus unshiu extract benefit to fight against atopic symptoms induced by indoor pollution.
    Household and Personal Care Today, 2018, 13(2): 4-7.
  • 23. Air Pollution and Skin Health: Recent Studieds.
    The Journal of Skin Barrier Research, 2018, 20(2) :15-17.
  • 24. Anti-skin Aging Effect of Pleurotus citrinopileatus Extracts.
    The Korean Society of Cosmetics and Cosmetology, 2018, 08(3): 345-353.
  • 25. Effect of Torreya nicifera Seed Extract on the cross-linking of Adavanced Glycation End Products to Collagen.
    J. Soc. Cosmet. Sci. Korea, 2019, 45(1): 19-25.
  • Book chapter : 3

    • 1. Asiaticoside Supports Collagen Production for Firmer Skin. In Aaron Tabor and Robert Blair (Eds.). Nutritional cosmetics: Beauty from Within. William Andrew Publishing, New York, 2009, pp. 335-352.
    • 2. Molecular targets and therapeutic uses of rosmarinic acid (Rosemary). In Bharat B. Aggarwal and Ajaikumar B. Kunnumakkara (Eds.). Molecular targets and therapeutic uses of Spices: Modern uses for ancient medicine.
      World Scientific Publishing, Singapore, 2009, pp. 341-371.
    • 3. Study of sliming agents from natural plants. In Chang-Gu Hyun and Nam Ho Lee (Eds.). Complementary and alternative medicine-botanical cosmeceuticals. Transworld Research Network, India, 2011 pp. 1-22.